GMP -2-day workshop “Physiologically based Pharmacokinetic (PBPK) Modeling” (8-9 Decembre 2022 – Marseille): Registration open

Dear Colleagues and Members,

We are happy to announce that registrations for the 1st 2-day workshops on PBPK modeling co-organized by the directors of the Master 2 in PK (Lyon, Marseille, Paris, Rennes and Toulouse), PhinC Development and the GMP are open. This workshop will be held on 8 & 9 December at Marseille.

This workshop is designed to provide participants with the necessary information needed for Physiologically Based Pharmacokinetic (PBPK) modeling. New Chemical and Biological Entities will be considered when applicable. You can find the program hereafter.

The number of participants is limited to 30:

  • 20 students registered in one of the 5 Master co-organizing this workshop (please contact the director of your Master if you are interested) – Fee: free registration
  • 10 industrial/academic delegates – Fee: 750 € (700 € for registration + 50 € for GMP membership)

You can find all relevant information (program, speakers, location…) in the attached document or on the GMP website.

For registration and information, please contact Fabrice Hurbin (fabrice.hurbin@sanofi.com)

Best regards

Workshop PBPK_8-9 décembre 2022_Final version

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Thursday 8 December 2022: Keynote lectures

Time Title Speakers
9:45 – 9:50 Welcome GMP
09:50 – 11:20 Prediction of human pharmacokinetics from preclinical data

  • Cross species extrapolation in PBPK
  • Use of in vitro data to predict Pharmacokinetics
  • Use of in vitro data to predict Pharmacodynamics
Donato Teutonico
(Sanofi)
11:20 – 11:45 Coffee break  
11:45 – 13:15 Biopharmaceutic

  • Food effect prediction
  • Formulation optimization
  • IVIVC with PBPK
Letizia Carrara
(Servier)
13:15 – 14:15 Lunch  
14:15 -15:45 Special populations

  • Maternal PBPK modeling
  • Lactational PBPK modeling
Marc Codaccioni
(Certara)
15:45 – 16:15 Coffee break  
16:15 – 17:45 Environmental & toxicologic applications

  • Development of PBPK models for data-poor chemicals
  • Interpretation of human biomonitoring data
  • Derivation of regulatory thresholds
Céline Brochot (INERIS)
From 18:30 Cocktail  

Friday 9 December 2022: Hands-on exercises

Time Title Facilitators
8:30 – 12:30* Building a PBPK model

  • Case study of hydrocodone (CYP3A4 and CYP2D6 substrate)
  • Modeling of parent drug and metabolite
Florence Gattacceca
(Aix-Marseille Université)

 

Kahina Haouchine
(PhinC)

 

Jeremy Perrier
(PhinC)

12:30 – 14:00 Lunch
14:00 – 17:30* Subgroup 1
(15 delegates)
Subgroup 2
(15 delegates)
  Biopharmaceutic applications

  • Modeling extended release (ER) tablets using in vitro data
  • Prediction of exposure with different ER tablets
DDI applications

  • Case study with paroxetine, a strong inhibitor of CYP2D6
* Including a coffee break